Rare diseases, as the European Union defined, are conditions that affect fewer than 1 out of 2000 people, which are also known as orphan diseases as the pharmaceutical industry previously was not interested in developing treatments for them due to possibly less profitability and higher investment. However, approximately 10,000 rare diseases are increasingly challenging worldwide health and…

Recently, it is reported that some stunning breakthroughs have been made in gene-editing techniques to treat diversified diseases. Clustered regularly interspaced short palindromic repeat (CRISPR) is such a gene-editing achievement, which has attracted great attention because of its high efficiency. However, the usage of CRISPR is still limited by several barriers, such as the digestion by endonuclease…

Surface modification of stem cells has been proven to be a viable method for controlling cell fate into certain phenotypes, which is required to restore function in a specific environment. Cell surface engineering in stem cells could provide them desired characteristics and functions, which could be used in targeted delivery, biosensing, transfection, imaging, and cell fate…

An estimated 46 million adults suffer from rheumatic diseases in the United States. These are complex autoimmune and inflammatory diseases that cause the immune system to attack and damage the joints, tendons, ligaments, bones, muscles and sometimes involve damage to internal organs. Rheumatic diseases are responsible for 27 percent of all disability among the U.S.…

Ferment foods, enzymes, and other bioactive compounds entail microorganisms to be tightly connected to human beings. The past decade has been witnessed the discovery of an unprecedented increase in the number of novel bacterial species. Therefore, to unlock the genetic potential of these species, genetic toolboxes are urgently needed. Through cutting-edge gene-editing technology, the use of…

Profacgen, a state-of-the-art protein service provider that proving custom protein services in the biological field, now proudly provides customer-focused solutions, equipped with the latest technologies of protein-fluorophore bioconjugation, to fit its customers’ special interests. The use of fluorescence-based detection of single biomolecules under physiological conditions opens new doors for studying biological problems. Fluorophore bioconjugation technology…

A new study identifies the genetic basis behind the adaptation strategies used by plants to cope with the harsh natural environment. These adaptation strategies include enriching the growth-promoting bacteria in the roots and actively selecting genes necessary for survival, which may be used to guide the cultivation of crops to make them more adaptable to…

As a global leading supplier of raw materials, antibodies, and reagents for bio-technology industry, Creative Diagnostics has launched a comprehensive list of immunohistochemistry antibodies for pathology. All the IHC antibodies are for research use only and not intended for diagnostic use. Immunohistochemistry (IHC) is used in histology to detect the presence of specific protein marker that…

Human endogenous metabolic compounds are some of the metabolites produced and found in the human body. The role of these metabolites cannot be underestimated. And this article will mainly introduce its application in disease diagnosis and drug discovery. 1  Endogenous metabolites can be used for disease diagnosis Diseases lead to changes in the body’s pathophysiological processes, and…

Toxicity risk 1. Antibody molecule At present, the antibody molecules of ADC drugs often use humanized monoclonal antibodies to modify the crystallizable fragment (Fc) segment to reduce antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependence. Complement dependent cytotoxicity (CDC), etc. First of all, as a biological macromolecule, antibody molecules have the toxicity risks of general biological…