It has been 35 years since the FDA approved the first monoclonal antibody in 1986. Antibody-based drugs account for nearly one-fifth of new FDA drug approvals each year. In this time, antibody engineering has changed dramatically. Current antibodies are the mainstream in new drug development because of their high specificity and low adverse effects, which have become the…

CD BioGlyco, a world leading biotechnology company that is committed to discovering, developing, manufacturing and providing innovative glycobiology-related high quality products and services, now provides multi-platform method for quantitative analysis of glycoproteins.   Protein glycosylation is one of the major post-translational modifications that can significantly affect protein folding, distribution, stability, conformation, and activity. Glycoprotein abundance,…

1. The definition and structure of carbon radicals When a bond is split, atoms or groups with lone electrons are generated, which are called free radicals. Free radicals with lone electrons on hydrogen atoms are called hydrogen radicals. Free radicals with lone electrons on carbon atoms are called carbon radicals. When the carbon-hydrogen bonds in…

Biological mass spectrometry-based proteomics analysis methods mainly include Bottom-up and Top-down methods. Ÿ Bottom-up is a traditional method that (enzymatically) digests a mixture of large fragments of proteins into small fragments of peptides and then analyzes them. It is widely used in proteomics research. Ÿ Top-down technology can directly analyze intact proteins, including post-translationally modified proteins and other…

Energy conversion Mitochondria are the site of oxidative metabolism in eukaryotes, and the place where carbohydrates, fats and amino acids are finally oxidized to release energy. The common pathway of final oxidation that mitochondria is responsible for is the tricarboxylic acid cycle and oxidative phosphorylation, which correspond to the second and third stages of aerobic…

Scientists in the field of plant research now have access to Lifeasible’s plant chromosome karyotype analysis services supported by up-to-date technologies.   Karyotype analysis of plant chromosomes is a technique in which metaphase chromosomes are analyzed, compared, sorted and numbered by banding technique according to the characteristics of chromosome length, centromere position, and proportion of long and…

Probiotics refer to a certain number of live microorganisms that can have a beneficial effect on the health of the host. At present, there are more than 20 kinds of probiotics used in China, mainly including Bifidobacterium, Lactobacillus, Clostridium butyricum, Saccharomyces boulardii, Enterococcus, Bacillus licheniformis and Bacillus cereus. Probiotics have eight major functions.   1.…

Gene therapy and oligonucleotide drugs can alleviate or cure many diseases that traditional means cannot cope with, especially those caused by gene defects or abnormalities. Naked nucleic acids are easily degraded by enzymes in tissues or cells, and the effect of cellular uptake is poor. Therefore, scientists are committed to developing delivery vehicles to transport…

Peptide labeling and modification At present, the content of polypeptide labeling and modification is very much, and it is widely used in the research of polypeptide medicine, polypeptide biology, polypeptide antibody and polypeptide reagent. Currently widely used are: non-radioactive nuclide labeling (C13, H2, N15), fluorescent labeling (FAM, FITC, etc.), biotin labeling, phosphorylation modification, etc. 1. Non-radioactive…

Monomers are molecules that can react together with other monomer molecules to form a larger polymer chain or three-dimensional network in a process called polymerization.There are mainly four types of monomers, including sugars, amino acids, fatty acids, and nucleotides, and each of these monomer types plays an important role in the existence and development of life,…